Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB)
Overview
Buyer
Place of Performance
NAICS
PSC
Set Aside
Original Source
Timeline
Qualification Details
Fit reasons
- NAICS alignment with historical contract wins in similar service areas.
- Scope strongly matches core technical capabilities and delivery model.
Risks
- Past performance thresholds may require one additional teaming partner.
- Potential clarification needed on staffing minimums before bid/no-bid.
Next steps
Validate eligibility requirements, assign capture owner, and schedule partner outreach to confirm teaming strategy before submission planning.
Quick Summary
The National Institute of Allergy and Infectious Diseases (NIAID), under the National Institutes of Health (NIH), is soliciting proposals for the continuation of the Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB). This initiative focuses on coordinating and conducting the design, synthesis, in vitro testing, and distribution of chemical libraries targeting Gram-negative bacterial pathogens and other antibiotic-resistant bacteria. Proposals are due May 8, 2026.
Scope of Work
The contract requires services in four key areas: 1) Library Design, 2) Compound Synthesis, 3) Compound Testing, and 4) Compound Management, including project management across all efforts. Key deliverables include the production of approximately 80 compounds per library, development of Individual Library Production Plans (ILPPs), and submission of various reports (ILPP-R, SSR, CTR, Monthly/Annual Progress, Final). Adherence to NIH policies on reproducibility, public access, and dual-use research, as well as compliance with regulations for select biological agents, is mandatory.
Contract & Timeline
- Contract Type: Solicitation (RFP)
- Anticipated Base Period: February 1, 2027 – January 31, 2028
- Option Periods: Extend through January 31, 2035
- Set-Aside: None (Not set-aside for small business)
- NAICS Code: 541714 (Health R&D Services; Applied Research) with a 1000-employee size standard
- RFP Available: April 8, 2026, on SAM.gov
- Proposal Due: May 8, 2026, by 7:00 PM ET
- Published Date: April 3, 2026
Evaluation Factors
Proposals will be evaluated based on:
- Technical Plan/Approach: 50%
- Technical Personnel: 20%
- Project Management: 20%
- Facilities, Equipment, Resources: 10%
- Price, Past Performance, and Subcontracting Program Evaluation Criteria will also be considered.
Submission & Contact
Proposals must be submitted electronically via the NIAID electronic Contract Proposal Submission (eCPS) website (https://ecps.nih.gov/). For inquiries, contact Ignacio Reyes, Contracting Officer, at ignacio.reyes@nih.gov or 301-435-7574.