Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Proposers' Day
Overview
Buyer
Place of Performance
NAICS
PSC
Set Aside
Original Source
Timeline
Qualification Details
Fit reasons
- NAICS alignment with historical contract wins in similar service areas.
- Scope strongly matches core technical capabilities and delivery model.
Risks
- Past performance thresholds may require one additional teaming partner.
- Potential clarification needed on staffing minimums before bid/no-bid.
Next steps
Validate eligibility requirements, assign capture owner, and schedule partner outreach to confirm teaming strategy before submission planning.
Quick Summary
This Special Notice announces a Proposers' Day for the ARPA-H Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. The event will be held on Wednesday, March 11, 2026, to introduce the program's goals and facilitate teaming. Registration is required by March 9, 2026.
Program Overview
The CIRCLE program, managed by the Advanced Research Projects Agency for Health (ARPA-H), aims to develop innovations in systems immunology. The objective is to reduce patient time in the ICU and improve outcomes by assessing, predicting, and treating immuno-inflammatory dysregulation. This involves defining novel control points through computational models to direct personalized immune reprogramming.
Proposers' Day Details
- Event: Hybrid Proposers' Day (PD)
- Date: March 11, 2026
- Location: Arlington, VA (and virtually)
- Purpose: Introduce CIRCLE program vision, clarify logistics, answer questions, and encourage teaming.
- Registration: Required by March 9, 2026, and is free of charge.
Program Structure & Components
CIRCLE is a three-phase, five-year initiative. It will involve two types of performers:
- Integrated Teams: Working on three Technical Areas (TAs):
- Measure: Dynamic Immune Descriptor
- Model: Digital Twin Generator
- Modulate: Rational Immune Reprogrammer
- Acceleration Platforms (APs): Up to three performers focused on:
- Clinical Data & Analysis Platform
- FDA-compliant Digital Twin Platform
- Critical Illness Clinical Trials Platform
Contract & Timeline
- Type: Special Notice (Informational)
- Published: February 17, 2026
- Proposers' Day Registration Deadline: March 9, 2026, at 4:00 PM ET
- Proposers' Day Event: March 11, 2026
- Set-Aside: None specified
Additional Notes
This notice is for informational purposes only and does not constitute a formal solicitation. The full CIRCLE Innovative Solutions Opening (ISO) solicitation (ARPA-H-SOL-26-139) is posted on SAM.gov. Interested parties are invited to submit "teaming profiles" to facilitate collaboration. Questions should be directed to the CIRCLE Ask-A-Question site. ARPA-H will not reimburse costs or provide feedback on submitted information related to this notice.
Contact Information
- Primary Contact: CIRCLE ISO Coordinator (CIRCLE@ARPA-H.gov)