Request for Information (RFI)
This RFI seeks information on software solutions to reduce inappropriate polypharmacy and potentially inappropriate medication (PIM) use among Veterans. The VA is looking for tools that can identify cumulative multi-drug interactions, optimize medication regimens, and assist in managing Veteran medication regimens. This RFI is for planning purposes only and is not a solicitation for quotes or proposals. No funds have been authorized for this effort.
Polypharmacy, the concurrent use of multiple medications, increases the risk of adverse drug events, medication non-adherence, drug-drug interactions, and healthcare costs. The VA is particularly interested in solutions that address polypharmacy in Veterans with Post Traumatic Stress Disorder (PTSD) and other mental health conditions, who are often prescribed multiple medications.
The VA requires an easy-to-use tool to facilitate optimal treatment for each Veteran, supporting shared decision-making.
Automated presentation of active and inactive medications (VA and community).
Automated evidence-based risk score for inappropriate polypharmacy, identifying high-risk patients.
Identification of specific risk factors for negative outcomes (e.g., hospice, cognitive disorders, age, frailty, number of ED visits/hospitalizations).
Automated generation of suggested evidence-based risk scores for individual medications.
Facilitation of informed shared clinical decision-making by providing drug information, indications, interactions, side effects, and educational materials.
Recording of adverse events and interface with VA communication tools for reconciliation and reminders.
Support for collaboration and shared treatment planning across clinical teams.
Minimization of time for clinical decision-making regarding treatment changes.
Recommendations to healthcare providers that offer options rather than directives.
Compliance with VA IT requirements (e.g., FedRAMP, ATO).
Secure handling of Patient Health Information (PHI) and Personally Identifiable Information (PII).
Interoperability with VA systems, including bidirectional data exchange and secure APIs.
Ability to facilitate review of individual patient and population clinical outcomes.
Respondents must indicate how their solution meets the clinical and critical requirements.
For unmet requirements, provide plans, estimated costs, and timelines.
Provide data showing software effectiveness, validated algorithms, and IT compliance.
Identify specific scientific sophistication, deployment numbers, processing speed, and clinical efficiency.
Explain software structure, implementation, and costs.
Indicate operational readiness by November 15, 2025.
Responses are due by September 15, 2025, via email.
This is an RFI only; no contract will be awarded based on responses.
Information submitted is voluntary and becomes government property.
Set-aside decisions may be made based on responses.
The requirement may be delayed, canceled, or revised.