NOI- Preparation of chemical compounds needed for a Janus kinase 2 (JAK2) enzyme project
Overview
Buyer
Place of Performance
NAICS
PSC
Set Aside
Original Source
Timeline
Qualification Details
Fit reasons
- NAICS alignment with historical contract wins in similar service areas.
- Scope strongly matches core technical capabilities and delivery model.
Risks
- Past performance thresholds may require one additional teaming partner.
- Potential clarification needed on staffing minimums before bid/no-bid.
Next steps
Validate eligibility requirements, assign capture owner, and schedule partner outreach to confirm teaming strategy before submission planning.
Quick Summary
The National Institutes of Health (NIH) / National Center for Advancing Translational Sciences (NCATS) has issued a Notice of Intent (NOI) to Sole Source for the preparation of specific chemical compounds needed for a Janus kinase 2 (JAK2) enzyme project. These compounds are crucial for evaluating brain cancer models to identify targets and specificity. The government intends to award a non-competitive contract to KareBay BioChem INC. Interested parties may submit capability statements by May 4, 2026, at 4:00 pm EST.
Purpose & Objectives
NCATS requires the synthesis of two specific chemical compounds and their analogs for evaluation in brain cancer models. This research aims to determine compound targets and provide insight into their specificity for brain cancer cells, supporting the development of JAK2 inhibitors for conditions like cancer and inflammatory diseases.
Scope of Work
The contractor will be responsible for furnishing all necessary services, qualified personnel, material, equipment, and facilities to synthesize the following compounds:
- 10g of 4-amino-N,N-dicyclopropyl-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide.
- 2.5g of N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide. Both compounds must be delivered at 95% purity, confirmed by NMR and LCMS. The contractor must also provide biweekly progress reports.
Contract Details
- Type: Pre-Solicitation Non-Competitive (Notice of Intent to Sole Source).
- NAICS Code: 325199 (All Other Basic Organic Chemical Manufacturing).
- Set-Aside: This acquisition is NOT set aside for small businesses.
- Period of Performance: Two months after receipt of an approved order.
- Regulatory Authority: FAR Part 12 (Acquisition of Commercial Items) in conjunction with FAR Part 13 (Simplified Acquisition Procedures).
- Statutory Authority: FAR 6.302-1 (Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements).
- Intended Source: KareBay BioChem INC, Fredonia, New York.
Submission & Evaluation
This synopsis is not a request for competitive proposals. The government's determination to award a contract without full and open competition is based on market research indicating KareBay BioChem INC is the only vendor capable of meeting the requirement due to proprietary equipment. However, responsible sources may submit a capability statement, proposal, or quotation to establish their bona-fide capabilities. Responses should include unit price, list price, shipping/handling, delivery period, prompt payment terms, F.O.B. Point, DUNS, TIN, and business size certification. All offerors must have an active SAM.gov registration.
Response Information
- Response Due: May 4, 2026, at 4:00 pm EST.
- Submission: Electronically to Jaddua Johnston, Contract Specialist, at Jaddua.Johnston@nih.gov.
- Point of Contact: Jaddua Johnston, 240-569-0006.
Additional Notes
The government will have sole possession of all generated compounds and data. Strict confidentiality is expected from the contractor, and any publications require approval from Juan Marugan.