NOI - Whole Genome Sequencing-Sickle Cell Patient
Overview
Buyer
Place of Performance
NAICS
PSC
Set Aside
Original Source
Timeline
Qualification Details
Fit reasons
- NAICS alignment with historical contract wins in similar service areas.
- Scope strongly matches core technical capabilities and delivery model.
Risks
- Past performance thresholds may require one additional teaming partner.
- Potential clarification needed on staffing minimums before bid/no-bid.
Next steps
Validate eligibility requirements, assign capture owner, and schedule partner outreach to confirm teaming strategy before submission planning.
Quick Summary
The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, intends to award a firm-fixed-price purchase order on a non-competitive basis to The Broad Institute, Inc. for Whole Genome Sequencing (WGS) services for sickle cell disease (SCD) patient samples. This acquisition supports ongoing genomic research and predictive modeling efforts. Responses regarding this Notice of Intent are due May 29, 2026.
Scope of Work
This requirement is for high-quality WGS services for 250 additional human genomic DNA samples derived from SCD patient blood. Key requirements include:
- Coverage Depth: Minimum average of 60X coverage per sample.
- Library Preparation: Standard PCR-free or equivalent high-fidelity preparation.
- Sequencing Platform: Illumina-based high-throughput platforms or equivalent.
- Data Quality: Metrics such as ≥80-90% of bases at ≥30X coverage, high alignment rates, and low duplication rates.
- Data Delivery: Secure electronic transfer via Broad-supported platforms or encrypted storage systems.
- Consistency: Use of standardized protocols consistent with prior sequencing batches to integrate new data with existing genomic and clinical datasets.
Contract & Timeline
- Contract Type: Firm-Fixed-Price Purchase Order
- Period of Performance: June 1, 2026, to September 30, 2026
- Estimated Value: Expected to be under the Simplified Acquisition Threshold.
- Set-Aside: None (non-competitive)
- Response Due: May 29, 2026, at 9:00 AM EDT
- Published: May 15, 2026
Evaluation
This is a Notice of Intent to award non-competitively. The government intends to award to The Broad Institute, Inc. due to their unique position, prior sequencing of this specific cohort, and use of established pipelines aligned with existing datasets. Using another vendor would introduce data variability, require reprocessing/validation, and pose unacceptable technical and programmatic risk.
Additional Notes
Respondents interested in challenging the non-competitive nature must submit a capability statement demonstrating their ability to meet the requirements. Required information for responses includes unit price, list price, shipping/handling, delivery days, F.O.B. Point, product/catalog number, product description, and other factors for award decision. Respondents must also provide UEI, TIN, and business size certification, and have active SAM registration. The NAICS code is 541990 (All Other Professional, Scientific and Technical Services) with a small business size standard of $19.5M.