Notice of Intent to Sole Source- 10X Genomics

Notice of Intent to Sole Source / Solicitation

This is a pre-solicitation synopsis announcing the government's intent to award a contract for single-cell RNA sequencing reagents on a non-competitive (sole source) basis. The National Institute on Aging (NIA) requires these reagents to support research investigating immune cell infiltration in patients with Alzheimer's disease by performing single-cell RNA sequencing on CSF samples.

• Reagents compatible with the 10x Genomics Chromium platform.

• Specifically: Library Construction Kit, 16 reactions (Part No. 1000190) and GEM-X Universal 5' Gene Expression v3, 16 samples.

• Associated shipping and handling.

• Reagents must be capable of partitioning cells into Gel Beads-in-Emulsion (GEMs), support 5' gene expression profiling, enable single-cell barcoding, and be validated for human CSF samples to generate high-quality cDNA libraries.

• This is a supply purchase; period of performance is not applicable, but standard manufacturer warranty provisions apply.

• Delivery is required within 30 days after contract award.

• This is NOT a request for competitive proposals. However, interested parties can identify their interest and capability.

• Responses should include unit price, list price, shipping and handling costs, delivery period, prompt payment discount terms, F.O.B. Point, DUNS number, TIN, and business size certification.

• All offerors must have an active registration in SAM.gov.

• Responses must be received by April 17, 2026, at 4:00 pm EST.

• Responses must be submitted electronically to Jaddua Johnston (Jaddua.Johnston@nih.gov) and reference Solicitation Number: PCA-NIA-02902.

• NAICS Code: 334516 - Analytical Laboratory Instrument Manufacturing (size standard 1,000 employees).

• This acquisition is not set aside for small business.

• The government intends to award to 10X Genomics as the sole responsible source.

• The government's determination for sole source is based on market research indicating 10X Genomics is the only vendor capable of meeting the requirement, as the equipment is proprietary.

• Information received may be used to determine whether to proceed on a non-competitive basis or conduct a competitive procurement.

Form / Attachment / Pricing Sheet

This document, titled "Product Description," outlines the specific requirements for single-cell RNA sequencing (scRNA-seq) reagents needed by the National Institute on Aging (NIA) for research into Alzheimer's disease.

• Statement of Need: To investigate immune cell infiltration in the cerebrospinal fluid (CSF) of Alzheimer's patients using scRNA-seq on approximately 60 human CSF samples.
• Product: Single-cell RNA sequencing (scRNA-seq) reagents for cell partitioning, barcoding, and library preparation.
• Compatibility: Must be compatible with the 10x Genomics Chromium platform and controller system.
• Specific Components Required:
  • Library Construction Kit, 16 reactions (Part No. 1000190)
  • GEM-X Universal 5' Gene Expression v3, 16 samples
• Technical Characteristics: Reagents must partition cells into Gel Beads-in-Emulsion (GEMs), support 5' gene expression profiling, integrate single-cell barcoding, and have validated performance for human biological samples (including CSF).
• Quantity: 2 kits of Library Construction Kit (16 reactions each) and 1 kit of GEM-X Universal 5' Gene Expression v3 (16 samples).
• Delivery: Within thirty days after contract award to Robert W. Maul, PhD. at the Biomedical Research Center in Baltimore, MD.

This document details the exact reagents, quantities, and technical specifications required for a supply purchase. Bidders must be able to provide these specific 10x Genomics compatible reagents to fulfill the NIA's research needs for Alzheimer's disease studies.