Resilient Systems Office (RSO) Mission Office Innovative Solutions Opening (ISO)

SOL #: ARPA-H-SOL-24-103Solicitation

Overview

Buyer

Health And Human Services

National Institutes Of Health

ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)

Washington, DC, 20005, United States

Place of Performance

Place of performance not available

NAICS

Research and Development in the Physical (541715)

PSC

Health R&D Services; Health Care Services; Experimental Development (AN13)

Set Aside

No set aside specified

Original Source

https://sam.gov/opp/2fe82425541c4b6f92713d9812721be4/view

Timeline

Posted

Mar 14, 2024

Last Updated

Jan 8, 2026

Submission Deadline

Mar 6, 2029, 4:59 AM

Qualification Details

Fit reasons

NAICS alignment with historical contract wins in similar service areas.
Scope strongly matches core technical capabilities and delivery model.

Risks

Past performance thresholds may require one additional teaming partner.
Potential clarification needed on staffing minimums before bid/no-bid.

Next steps

Validate eligibility requirements, assign capture owner, and schedule partner outreach to confirm teaming strategy before submission planning.

Quick Summary

The Advanced Research Projects Agency for Health (ARPA-H), under the National Institutes of Health, has issued a Solicitation for its Resilient Systems Office (RSO) Mission Office Innovative Solutions Opening (ISO). This opportunity seeks cutting-edge solutions to address systemic challenges in healthcare and public health. Amendment 3 provides critical updates to submission requirements. There is no set-aside for this opportunity.

Purpose and Scope

ARPA-H's RSO is investing in innovative technologies to improve the quality, efficacy, and consistent availability of care across the healthcare and public health landscape. This ISO invites solution summary and proposal submissions for projects aligned with the RSO mission.

Contract Details & Key Updates

Opportunity Type: Solicitation
Product Service Code: AN13 (Health R&D Services; Experimental Development)
Set-Aside: None
Amendment 3 Details:
- Administrative & National Policy Requirements: Updates to Organizational Conflicts of Interest (OCI), Research Security, and Intellectual Property (IP) sections, including new definitions and a consolidated data assertions chart. Human Subjects Research (HSR) and Animal Subjects Research (ASR) tables, and Biosecurity questions were updated. The "Software Component Standards" section was eliminated.
- Cost Proposal Document: Clarified definitions for "burdened labor rate" and "fully burdened labor rate." The unit cost threshold for supporting documentation for planned materials and equipment purchases increased from $5,000 to $10,000.
- Cost Proposal Workbooks: Instructions updated regarding profit/fee assumption if not included and supporting documentation for material/equipment purchases.

Submission Process & Requirements

Proposers must first submit a Solution Summary and receive feedback before submitting a full proposal.

Solution Summary Template (Appendix A): This mandatory template outlines key elements including a Cover Page, Sub-Awardee/Consultant Team, Concept Summary, Innovation and Impact, Proposed Work, Team Organization, and Basis of Estimate (BOE). It specifies a six-page limit (excluding citations) and formatting requirements.
Submission Portals:
- Solution Summary: https://solutions.arpa-h.gov
- Proposal Submission: https://solutions.arpa-h.gov/Submit-Proposal/

Key Dates

Original Published Date: January 8, 2026
Amendment 3 Release Date: October 14, 2025
Solution Summary Deadline: March 5, 2029
Proposal Deadline: Within 45 days of receiving Solution Summary feedback (or alternative timeline).