One Comprehensive Universal Radiotherapy for Everyone (1-CURE) Proposers' Day
Overview
Buyer
Place of Performance
NAICS
PSC
Set Aside
Original Source
Timeline
Qualification Details
Fit reasons
- NAICS alignment with historical contract wins in similar service areas.
- Scope strongly matches core technical capabilities and delivery model.
Risks
- Past performance thresholds may require one additional teaming partner.
- Potential clarification needed on staffing minimums before bid/no-bid.
Next steps
Validate eligibility requirements, assign capture owner, and schedule partner outreach to confirm teaming strategy before submission planning.
Quick Summary
The Advanced Research Projects Agency for Health (ARPA-H) has issued a Special Notice announcing a Proposers' Day for its new "One Comprehensive Universal Radiotherapy for Everyone" (1-CURE) program. This event aims to inform the scientific community about the program's technical areas and facilitate teaming for an anticipated Innovative Solutions Opening (ISO). The 1-CURE program seeks to develop revolutionary radiotherapy effective against all cancers. Registration for the Proposers' Day is required by March 23, 2026.
Program Overview
The 1-CURE program's objective is to develop a revolutionary radiotherapy approach effective against all cancers, utilizing FLASH-RT technology integrated with immunogenic smart radiotherapy biomaterials (SRBs). The program is structured into two key technical areas:
- TA1: Immunogenic Nanoparticle SRBs
- TA2: Abscopal Treatment Planning System for Low-cost FLASH-RT Applicants for the forthcoming ISO will be required to submit comprehensive proposals addressing both TA1 and TA2.
Proposers' Day Details
The Proposers' Day is an optional but encouraged event designed to provide detailed information on the 1-CURE program's goals, solution summary, proposal structure, scope, timeline, and scale. The event format includes:
- Overview presentations
- 3-minute lightning talks
- 5-minute sidebar meetings Participants are encouraged to prepare a one-page slide for lightning talks (a template is provided) and a one-page "teaming profile" to identify potential partners. Registration is required and open until the day of the event, with no same-day registration available.
Opportunity Details
- Type: Special Notice (announcing an anticipated Innovative Solutions Opening - ISO)
- Agency: Advanced Research Projects Agency for Health (ARPA-H), under the National Institutes of Health (NIH), Health and Human Services.
- Anticipated ISO Release: No later than March 16, 2026
- Proposers' Day Registration Deadline: March 23, 2026 (4:00 PM ET)
- Published Date: March 12, 2026
- Set-Aside: None
- Product Service Code: AN13 (Health R&D Services; Health Care Services; Experimental Development)
Action Items
Interested parties should register for the Proposers' Day, prepare their lightning talk slides and teaming profiles, and monitor for the release of the forthcoming 1-CURE Innovative Solutions Opening. Contact: The 1-CURE Team (1-CURE@ARPA-H.gov)