Proactive Health Office (PHO) Mission Office Innovative Solutions Opening (ISO)
Overview
Buyer
Place of Performance
NAICS
PSC
Set Aside
Original Source
Timeline
Qualification Details
Fit reasons
- NAICS alignment with historical contract wins in similar service areas.
- Scope strongly matches core technical capabilities and delivery model.
Risks
- Past performance thresholds may require one additional teaming partner.
- Potential clarification needed on staffing minimums before bid/no-bid.
Next steps
Validate eligibility requirements, assign capture owner, and schedule partner outreach to confirm teaming strategy before submission planning.
Quick Summary
The Advanced Research Projects Agency for Health (ARPA-H), specifically its Proactive Health Office (PHO), has issued an Innovative Solutions Opening (ISO) to solicit groundbreaking solutions. The objective is to significantly improve the healthspan and health outcomes of Americans by preventing disease onset and mitigating the impact of illness. This initiative focuses on population-level prevention, wellness promotion, novel early-detection methods, prophylactic interventions, and system-level innovations for effective proactive health delivery. Solution Summaries are due by March 5, 2029.
Scope of Work
ARPA-H PHO is seeking solutions addressing three core hypotheses:
- Population-level improvements in access to and uptake of disease prevention and wellness-promoting behaviors.
- Development of novel early-detection methods and prophylactic interventions to drastically improve health throughout life.
- System-level innovations required for the effective delivery of proactive health.
Contract & Timeline
- Type: Solicitation (Innovative Solutions Opening - ISO)
- Agency: Health And Human Services / National Institutes of Health / ARPA-H
- Product Service Code: AN13 (Health R&D Services; Health Care Services; Experimental Development)
- Set-Aside: None
- Solution Summary Due: March 5, 2029
- Proposal Submission: Within 45 days of receiving feedback on the Solution Summary.
- Published Date: June 10, 2026 (reflecting Amendment 04)
Submission Requirements & Updates
Submissions for Solution Summaries and proposals, along with questions, must be made through the ARPA-H Solutions Site (https://solutions.arpa-h.gov).
Amendment 04, posted June 10, 2026, is effective immediately and includes:
- An updated Administrative and National Policy Requirements document.
- Minor changes throughout the ISO, including updating the portal name to ARPA-H Solutions Site and revised language in Section 6.1 Research Security Disclosures.
- Clarifications regarding the eligibility and involvement of FFRDCs and government entities. Offerors who have only submitted a Solution Summary must ensure any future proposal complies with Amendment 04. The Appendix A - ARPA-H Solutions Summary Template (6-page limit) outlines required content including concept, innovation, proposed work, team, and basis of estimate.