Office-Wide Innovative Solutions Opening for Proactive Health Office (PHO)
Overview
Buyer
Place of Performance
NAICS
PSC
Set Aside
Original Source
Timeline
Qualification Details
Fit reasons
- NAICS alignment with historical contract wins in similar service areas.
- Scope strongly matches core technical capabilities and delivery model.
Risks
- Past performance thresholds may require one additional teaming partner.
- Potential clarification needed on staffing minimums before bid/no-bid.
Next steps
Validate eligibility requirements, assign capture owner, and schedule partner outreach to confirm teaming strategy before submission planning.
Quick Summary
The Advanced Research Projects Agency for Health (ARPA-H), specifically its Proactive Health Office (PHO), has issued an Innovative Solutions Opening (ISO) seeking groundbreaking solutions to enhance the healthspan and health outcomes of Americans. This solicitation focuses on disease prevention, wellness promotion, novel early-detection methods, prophylactic interventions, and system-level innovations. Proposals are due by March 6, 2029.
Scope of Opportunity
ARPA-H PHO aims to address critical health challenges by fostering solutions that improve health before disease onset or diminished quality of life. The office hypothesizes that significant improvements can be achieved through:
- Population-level enhancements in access to and uptake of disease prevention and wellness-promoting behaviors.
- Development of novel early-detection methods and prophylactic interventions.
- System-level innovations for effective delivery of proactive health initiatives.
Key Amendment 3 Updates
This solicitation incorporates Amendment 3, which introduces several critical updates to proposal documents:
- Administrative & National Policy Requirements Document:
- Revised instructions and references for "Organizational Conflicts of Interest (OCI) Affirmations and Disclosure."
- Updated questions, instructions, and content in the "Research Security Disclosure" section.
- Modified "IP" section with updated instructions, intellectual property data assertions charts, definitions of rights categories (unlimited, government purpose, limited, specially negotiated/other), and consolidated data assertion tables.
- Eliminated the "Software Component Standards" section.
- Updated Human Subjects Research (HSR) and Animal Subjects Research (ASR) tables.
- Revised questions and instructions in the "Biosecurity" section.
- Cost Proposal Document:
- Updated instructions in "Level of Effort and Labor Costs," adding definitions for "burdened labor rate" and "fully burdened labor rate."
- Increased the threshold for supporting documentation for planned materials and equipment purchases from $5,000 to $10,000 unit cost.
- Cost Proposal Workbooks:
- Clarified that ARPA-H will assume profit/fee is not applicable if not included.
- Updated instructions for supporting documentation based on the increased material/equipment threshold.
Submission Requirements
Proposers must submit a Solutions Summary using the provided Appendix A template. This template details required content including:
- Cover Page information (organization, POCs, project duration, BOE, resource sharing).
- Details on sub-awardees/consultants.
- A comprehensive Concept Summary addressing ISO interest areas, innovation, and impact.
- Description of Innovation and Impact, desired outcomes, and quantitative metrics.
- Detailed Proposed Work, including deliverables, milestones, technical approach, risks, and new developments.
- Team Organization and Capabilities.
- A thorough Basis of Estimate (BOE) for all project costs and resource sharing.
- Formatting requirements: English, sans-serif 11-point minimum, limited to six pages (excluding citations).
Solution summaries, questions, and proposals must be submitted via the ARPA-H solutions portal:
https://solutions.arpa-h.gov.
Contract & Timeline
- Opportunity Type: Solicitation (Innovative Solutions Opening)
- Product Service Code: AN13 (Health R&D Services; Health Care Services; Experimental Development)
- Set-Aside: None
- Published Date: January 8, 2026
- Response Due Date: March 6, 2029
Contact Information
Questions must be submitted through the ARPA-H solutions portal: https://solutions.arpa-h.gov/Ask-A-Question/. The provided email address (do_NOT_use_THIS_email_ADDRESS@arpa-h.gov) should not be used for inquiries.