BIOmolecular Grammar for protein Aggregation Modulation and Intervention (BIOGAMI) Proposers' Day

SOL #: ARPA-H-SN-26-147Special Notice

Overview

Buyer

Health And Human Services

National Institutes Of Health

ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)

Washington, DC, 20005, United States

Place of Performance

Washington, DC

NAICS

Research and Development in the Physical (541715)

PSC

Health R&D Services; Health Care Services; Experimental Development (AN13)

Set Aside

No set aside specified

Original Source

https://sam.gov/opp/fa625c986def42ecb5e4ab50d45685c8/view

Timeline

Posted

Jan 27, 2026

Last Updated

Feb 18, 2026

Action Date

Feb 19, 2026, 5:00 PM

Qualification Details

Fit reasons

NAICS alignment with historical contract wins in similar service areas.
Scope strongly matches core technical capabilities and delivery model.

Risks

Past performance thresholds may require one additional teaming partner.
Potential clarification needed on staffing minimums before bid/no-bid.

Next steps

Validate eligibility requirements, assign capture owner, and schedule partner outreach to confirm teaming strategy before submission planning.

Quick Summary

ARPA-H has issued a Special Notice (SN) for the BIOmolecular Grammar for protein Aggregation Modulation and Intervention (BIOGAMI) Proposers' Day. This event, detailed in Amendment 1, aims to inform the scientific community about the new BIOGAMI program, which seeks to transform therapeutic approaches for protein dysfunction. The Proposers' Day will be held on February 20, 2026, in a hybrid format.

Program Overview

The BIOGAMI program focuses on controlling protein folding to address diseases like neurodegenerative disorders, cancers, and diabetes. It aims to develop tools to predict and modulate protein misfolding and aggregation, and identify novel indicators for early detection. The program will have two technical areas (TA1: Molecular Grammar of IDRs, TA2: Modulate IDPs) and two phases, with proposals required to address both TAs in Phase 1.

Proposers' Day Details

Date: February 20, 2026
Location: Executive Conference Center, 4075 Wilson Boulevard, Suite 300, Arlington, VA 22203 (hybrid event)
Registration: Opens January 30, 2026. Closes February 18, 2026 (in-person, 5 PM ET) and February 19, 2026 (virtual, 12 PM ET). Advance registration is required via https://solutions.arpa-h.gov/BIOGAMI.
Purpose: Provide program goals, solution summary, and proposal structure for the forthcoming Innovative Solutions Opening (ISO), and facilitate collaboration.
Deliverables: Proposers are invited to submit a one-page "teaming profile" (capabilities, research areas, desired partners) via https://solutions.arpa-h.gov/Teaming. An optional 3-minute "Lightning Talk" presentation template is also provided for showcasing capabilities.
Format: Includes overview presentations, lightning talks, and limited private sidebar meetings (in-person on Feb 20, virtual on Feb 23).
Q&A: Live Q&A during the event, with answers published on the program's FAQ page.

Contract & Timeline

Opportunity Type: Special Notice
Published Date: February 6, 2026 (Amendment 1)
Response Date: February 19, 2026 (Virtual Registration Close)
Set-Aside: None specified

Additional Notes

Attendance at the Proposers' Day is optional and not a requirement for submitting a solution summary or proposal. This notice is for informational and planning purposes only and does not constitute a formal solicitation. No reimbursement will be provided for costs incurred in responding.