BIOmolecular Grammar for protein Aggregation Modulation and Intervention (BIOGAMI) Proposers' Day

Amendment / Modification

This document is Amendment 1 to Special Notice ARPA-H-SN-26-147, announcing a Proposers' Day for the BIOmolecular Grammar for protein Aggregation Modulation and Intervention (BIOGAMI) program.

• Proposers' Day Date: February 20, 2026.

• Location: Executive Conference Center, 4075 Wilson Boulevard, Suite 300, Arlington, VA 22203.

• Website for Registration: https://solutions.arpa-h.gov/BIOGAMI

• Registration Opens: January 30, 2026.

• Registration Closes: In-Person: February 18, 2026, 5 PM ET; Virtual: February 19, 2026, 12 PM ET.

• Technical Point of Contact: Dr. Shannon Greene, Program Manager, ARPA-H / HSF Office.

• Program Email: BIOGAMI@arpa-h.gov

• Proposer Deliverables for Proposers' Day:

  • One (1) PDF page "teaming profile" (capabilities, composition, research areas of interest, etc.).
  • Optional: 3-minute Lightning Talk presentation (format to be provided).

• Draw attention to BIOGAMI technical areas.

• Provide information on program goals, solution summary, and proposal structure for the forthcoming Innovative Solutions Opening (ISO).

• Share the scope, timeline, and scale of the BIOGAMI program.

• Provide an opportunity to identify potential collaborators.

• Overview presentations by government personnel.

• Lightning talks by proposers (3-minute limit).

• Five (5)-minute private sidebar meetings (limited availability for in-person attendees on Feb 20, 2026; virtual sidebar meetings on Feb 23, 2026).

• Proposers are invited to submit "teaming profiles" describing technical competencies, team capabilities, composition, research areas, facilities, and desired competencies from partners.

• Submission is via a specific link: https://solutions.arpa-h.gov/Teaming.

• Teaming profiles will be updated and available on the program's teaming site.

• Live Q&A session during Proposers' Day.

• Questions and answers will be published on the FAQ page: https://arpa-h.gov/research-and-funding/programs/BIOGAMI/faqs.

• Attendance at Proposers' Day is not a requirement for submitting a solution summary or proposal.

• Information from the PD will be made available on the ARPA-H Opportunities page and SAM.gov.

• Advance registration is required; no same-day registration.

• This Special Notice and Proposers' Day are for information and planning purposes only.

• It does not constitute a formal solicitation or offer.

• Submission of information is voluntary and not required for future proposals.

• No reimbursement for costs incurred in responding.

Form / Attachment / Pricing Sheet

This document is a template for a BIOGAMI Lightning Talk. It appears to be a presentation template intended for use by potential offerors to structure information about their capabilities and teaming goals.

• Core Capabilities and Team Strengths: A section for detailing the bidder's strengths.
• Contact Information: Fields for Point of Contact (POC), Institution, and Email address.
• Teaming Goals: A section to specify the type of expertise the bidder is seeking from potential partners.

This template provides a structured format for bidders to present their qualifications and teaming interests, likely as part of a proposal submission or pre-solicitation engagement. Bidders should use this template to organize and convey essential information about their company and their desired collaborations.

Amendment / Modification

This document is Amendment 1 to the Special Notice (SN) ARPA-H-SN-26-147, announcing a Proposers' Day (PD) for the BIOmolecular Grammar for protein Aggregation Modulation and Intervention (BIOGAMI) program. The amendment primarily provides updated information and clarifies details related to the Proposers' Day event.

Key updates include:

• Clarification of the Proposers' Day date: February 20, 2026.
• Updated registration closing dates for in-person and virtual attendees.
• Specification of "teaming profile" deliverables for proposers, including a "teaming profile" PDF and an optional 5-minute Lightning Talk presentation.
• Details on the structure and purpose of the Proposers' Day, including overview presentations, lightning talks, and private sidebar meetings.
• Information on how to submit teaming profiles and where they will be made available.
• Clarification on the Live Questions and Answers (Q&A) session and the availability of answers on a FAQ page.
• Details regarding Lightning Talks, including submission deadlines and purpose.
• Registration information, emphasizing advance registration and the hybrid nature of the event.
• Information on virtual attendance and virtual sidebar meetings.

This amendment affects sections related to the Proposers' Day announcement, including key information, deliverables, teaming profiles, Q&A, lightning talks, and registration details.

This amendment does not change the fact that attendance at the Proposers' Day is optional and not a requirement for submission of a solution summary or proposal. It provides further details and opportunities for potential proposers to understand the BIOGAMI program and identify collaborators.

Other / Unclassified

This document is a Special Notice (SN) announcing a Proposers' Day (PD) for the upcoming ARPA-H BIOGAMI (BIOmolecular Grammar for protein Aggregation Modulation and Intervention) Innovative Solutions Opening (ISO).

This notice is relevant to potential bidders interested in the BIOGAMI program. It provides information about:

• The BIOGAMI Program: Aims to transform therapeutic approaches for protein dysfunction in diseases like neurodegenerative disorders, cancers, and diabetes by controlling protein folding. It seeks to develop tools to predict and modulate protein misfolding and aggregation, and identify novel indicators for early detection.
• Proposers' Day (PD): An optional event to inform the scientific community about the BIOGAMI program, its goals, scope, and proposal structure. It offers opportunities for networking, understanding technical areas (TA1: Molecular Grammar of IDRs, TA2: Modulate IDPs), and potential collaboration.
• Key Dates & Registration: Proposers' Day is on February 20, 2026. Registration opens January 30, 2026, with closing dates of February 18, 2026 (in-person) and February 19, 2026 (virtual). Advance registration is required, and it is a hybrid event with no fee.
• Deliverables for PD: Attendees can submit a one-page "teaming profile" and optionally participate in 5-minute "Lightning Talks" to showcase capabilities.
• Program Structure: The program will have two technical areas (TA1 and TA2) and two phases (Phase 1: 24 months, Phase 2: 24 months). Proposals must address both TAs in Phase 1.
• Points of Contact: Dr. Shannon Greene (Program Manager) and the email BIOGAMI@arpa-h.gov are provided for inquiries.

This SN is for informational and planning purposes and does not constitute a formal solicitation.